Triterpenoid saponins from Albizia lebbeck (L.) Benth and their inhibitory effect on the survival of high grade human brain tumor cells. (2nd March 2015)

• Record Type: Journal Article
• Authors: Noté, Olivier Placide; Jihu, Dong; Antheaume, Cyril; Zeniou, Maria; Pegnyemb, Dieudonné Emmanuel; Guillaume, Dominique; Chneiwess, Hervé; Kilhoffer, Marie Claude; Lobstein, Annelise
• Is Part Of: Carbohydrate research. Volume 404(2015)
• Page Start: 26
• Page End: 33
• Publication Date: 2015-03-02
• Subjects: Albizia lebbeck -- Mimosaceae -- Triterpenoid saponins -- Lebbeckosides -- Cytotoxic activity; Carbohydrates -- Periodicals; Chemistry, Organic -- Periodicals; Biochemistry -- Periodicals; Carbohydrates -- Periodicals; Chimie organique -- Périodiques; Glucides -- Périodiques; Biochemistry; Carbohydrates; Chemistry, Organic; Periodicals; Electronic journals; 507.78
• DOI: 10.1016/j.carres.2014.12.004
• Languages: English
• ISSNs: 0008-6215

Abstract

Graphical abstract: Highlights: Two new bioactive avicins were isolated from the roots of Albizia lebbeck . Their structures were established by direct interpretation of their spectral data. They showed cytotoxic activity against U-87 MG and TG1 cancer cell lines. Abstract: As part of our search of new bioactive triterpenoid saponins from Cameroonian Mimosaceae plants, phytochemical investigation of the roots of Albizia lebbeck led to the isolation of two new oleanane-type saponins, named lebbeckosides A–B (1 –2 ). Their structures were established on the basis of extensive 1D and 2D NMR ( 1 H, 13 C NMR, DEPT, COSY, TOCSY, ROESY, HSQC, and HMBC) and HRESIMS studies, and by chemical evidence. Compounds1 –2 were evaluated for their inhibitory effect on the metabolism of high grade human brain tumor cells, the human glioblastoma U-87 MG cell lines and the glioblastoma stem-like TG1 cells isolated from a patient tumor, and known to be particularly resistant to standard therapies. The isolated saponins showed significant cytotoxic activity against U-87 MG and TG1 cancer cells with IC50 values of 3.46 μM and 1.36 μM for1, and 2.10 μM and 2.24 μM for2, respectively.