Theranostic magnetoliposomes coated by carboxymethyl dextran with controlled release by low-frequency alternating magnetic field. (15th March 2015)

• Record Type: Journal Article
• Authors: Guo, Hongyan; Chen, Wansong; Sun, Xiaoyi; Liu, You-Nian; Li, Juan; Wang, Jianxiu
• Is Part Of: Carbohydrate polymers. Volume 118(2015)
• Page Start: 209
• Page End: 217
• Publication Date: 2015-03-15
• Subjects: Liposome -- Carboxymethyl dextran -- Controlled release -- Magnetic resonance imaging -- Doxorubicin; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2014.10.076
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: Synthesis of carboxymethyl dextran-coated magnetoliposomes. Good stability in serum and high drug loading ability for doxorubicin. Enhanced drug release under low-frequency alternating magnetic field. High relaxivity ratio of r 2 to r 1 as T 2 -weighted contrast agent in MR imaging. A potential carrier for targeting diagnostic-therapy for cancers. Abstract: The aim of this work was to construct carboxymethyl dextran (CMD)-coated magnetoliposomes (MLs), another stealth MLs alternative to PEGylated MLs, for theranostic application. Particularly, the on-demand release of CMD-MLs under low-frequency alternating magnetic field (LF-AMF) was studied. We found that as-prepared MLs exhibited good stability and high drug loading ability for doxorubicin (DOX). Cytotoxicity assay against human neuroblastoma SH-SY5Y cells showed that the DOX-loaded CMD-MLs were less toxic than free DOX due to the sustained release of DOX. However, the release of DOX-loaded CMD-MLs was enhanced by low-frequency alternating magnetic field without hyperthermia generation. The MLs also acted as an efficient T 2 -weighted contrast agent during in vitro MRI measurements. The above results provide useful information on in vivo diagnostic/therapeutic efficacy of DOX-loaded CMD-MLs for some cancers, such as brain cancers.