Current and future strategies for the nutritional management of cardiometabolic complications of androgen deprivation therapy for prostate cancer. Issue 2 (13th June 2017)

• Record Type: Journal Article
• Authors: Turner, Lauren; Poole, Karen; Faithfull, Sara; Griffin, Bruce A.
• Is Part Of: Nutrition research reviews. Volume 30:Issue 2(2017)
• Page Start: 220
• Page End: 232
• Publication Date: 2017-06-13
• Subjects: Prostate cancer, -- Androgen deprivation therapy, -- Metabolic syndrome, -- Cardiometabolic risk, -- Nutritional management; Nutrition -- Periodicals; 613.2
• DOI: 10.1017/S0954422417000087
• Languages: English
• ISSNs: 0954-4224

Abstract

Abstract: Androgen deprivation therapy (ADT) is used widely as part of a combined modality for the treatment of prostate cancer. However, ADT has also been associated with the development of cardiometabolic complications that can increase mortality from cardiovascular events. There is emerging evidence to suggest that ADT-related cardiometabolic risk can be mitigated by diet and lifestyle modification. While the clinical focus for a nutritional approach for achieving this effect is unclear, it may depend upon the timely assessment and targeting of dietary changes to the specific risk phenotype of the patient. The present review aims to address the metabolic origins of ADT-related cardiometabolic risk, existing evidence for the effects of dietary intervention in modifying this risk, and the priorities for future dietary strategies.