Embracing rejection: Immunologic trends in brain metastasis. (2nd July 2016)

• Record Type: Journal Article
• Authors: Farber, S. Harrison; Tsvankin, Vadim; Narloch, Jessica L.; Kim, Grace J.; Salama, April K. S.; Vlahovic, Gordana; Blackwell, Kimberly L.; Kirkpatrick, John P.; Fecci, Peter E.
• Is Part Of: Oncoimmunology. Volume 5:Number 7(2016)
• Publication Date: 2016-07-02
• Subjects: Blood–brain barrier -- brain metastasis -- immune checkpoint blockade -- immunotherapy -- tumor microenvironment; Tumors -- Immunological aspects -- Periodicals; Neoplasms -- therapy -- Periodicals; Immunotherapy -- Periodicals; 616.994
• DOI: 10.1080/2162402X.2016.1172153
• Languages: English
• ISSNs: 2162-402X

Abstract

ABSTRACT: Brain metastases represent the most common type of brain tumor. These tumors offer a dismal prognosis and significantly impact quality of life for patients. Their capacity for central nervous system (CNS) invasion is dependent upon induced disruptions to the blood–brain barrier (BBB), alterations to the brain microenvironment, and mechanisms for escaping CNS immunosurveillance. In the emerging era of immunotherapy, understanding how metastases are influenced by the immunologic peculiarities of the CNS will be crucial to forging therapeutic advances. In this review, the immunology of brain metastasis is explored.