Brief Report: Effects of Tenofovir and Amphotericin B Deoxycholate Coadministration on Kidney Function in Patients Treated for Cryptococcal Meningitis. (1st January 2016)

• Record Type: Journal Article
• Authors: Kiggundu, Reuben; Morawski, Bozena M.; Bahr, Nathan C.; Rhein, Joshua; Musubire, Abdu K.; Williams, Darlisha A.; Abassi, Mahsa; Nabeta, Henry W.; Hullsiek, Kathy H.; Meya, David B.; Boulware, David R.
• Is Part Of: Journal of acquired immune deficiency syndromes. Volume 71:Number 1(2016)
• Publication Date: 2016-01-01
• Subjects: cryptococcal meningitis -- amphotericin B deoxycholate -- tenofovir -- renal toxicity; AIDS (Disease) -- Periodicals; Acquired Immunodeficiency Syndrome -- Periodicals; AIDS (Disease); Periodicals; 616.9792005
• DOI: 10.1097/QAI.0000000000000812
• Languages: English
• ISSNs: 1525-4135

Abstract

Abstract : Abstract: The effect of tenofovir and amphotericin coadministration on kidney function is poorly characterized. We measured creatinine during induction therapy and at 4 weeks after diagnosis in Ugandans undergoing cryptococcal meningitis therapy and classified as not receiving antiretroviral therapy (ART), receiving nontenofovir ART or receiving tenofovir-based ART. Longitudinal creatinine changes and grade 2–4 creatinine adverse events were evaluated across groups. Creatinine concentrations were similar across ART groups. At 4 weeks after diagnosis, creatinine was 0.25 mg/dL higher than at diagnosis, but similar across groups. Adverse event incidence was also similar across ART groups. Tenofovir and amphotericin coadministration did not increase the risk of kidney dysfunction.