The use of steroids to prevent cutaneous reactions to benznidazole in patients with Chagas disease. (April 2013)

• Record Type: Journal Article
• Authors: Górgolas, Miguel; Robles, Ignacio; Cabello, Alfonso; Pérez-Tanoira, Ramón; Peremarch, Concepción Pérez-Jorge; Fernández-Roblas, Ricardo; Williams, Frances; Rincón, José Manuel Ramos
• Is Part Of: Pathogens and global health. Volume 107:Number 3(2013)
• Page Start: 157
• Page End: 160
• Publication Date: 2013-04
• Subjects: Chagas disease -- Benznidazole -- Steroids -- Trypanosoma cruzi; Communicable diseases -- Periodicals; Public health -- International cooperation -- Periodicals; World health -- Periodicals; 362.1969
• DOI: 10.1179/2047773213Y.0000000081
• Languages: English
• ISSNs: 2047-7724

Abstract

Abstract : The treatment of Chagas disease is limited by the frequent cutaneous side effects of benznidazole. We tested the use of steroids plus escalating doses of benznidazole to prevent this complication in 17 adult patients with chronic Trypanosoma cruzi infection and found extremely good tolerance. A randomized trial is warranted.