Adverse effect of diabetes and hyperglycaemia on arterial stiffness in Europeans, South Asians, and African Caribbeans in the SABRE study. Issue 2 (February 2016)

• Record Type: Journal Article
• Authors: Park, Chloe M.; Tillin, Therese; March, Katherine; Jones, Siana; Whincup, Peter H.; Mayet, Jamil; Chaturvedi, Nish; Hughes, Alun D.
• Is Part Of: Journal of hypertension. Volume 34:Issue 2(2016:Feb.)
• Publication Date: 2016-02
• Subjects: arterial stiffness -- blood pressure -- diabetes -- ethnicity -- haemodynamics -- hyperglycaemia; Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/HJH.0000000000000789
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objectives: Ethnic minority groups in the UK experience marked differences in cardiovascular disease risk. We investigated differences in arterial central haemodynamics, stiffness, and load in a tri-ethnic population-based cohort. Methods: A total of 1312 participants (70 ± 6 years) underwent echocardiography and measurement of brachial and central blood pressure to assess central arterial haemodynamics including central pulse pressure (cPP), arterial stiffness [cPP/stroke volume (SV)], systemic vascular resistance (SVR), and load ( E a ). Results: Brachial and central SBPs were similar in all ethnic groups. Compared with Europeans, cPP, cPP/SV, and E a were higher in South Asians. In contrast, cPP/SV was lower in African Caribbeans despite higher mean arterial pressure, higher SVR, and higher diabetes prevalence. cPP/SV and E a remained significantly higher in South Asians and significantly lower in African Caribbeans after multivariate adjustment. Diabetes and higher HbA1c were more strongly associated with higher cPP/SV in South Asians than in Europeans ( P interaction = 0.045 and 0.005, respectively); higher HbA1c was also more strongly associated with increased E a in South Asians than Europeans ( P interaction = 0.01). There was no evidence of an interaction between glycaemia and cPP/SV in African Caribbeans. Conclusions: Compared with Europeans, South Asians have unfavorable arterial function. Diabetes and hyperglycaemia have a more deleterious effect on cPP/SV and E a in South Asians. In contrast, African Caribbeans have more favourable arterial function than Europeans and South Asians. These differences may contribute to the differential ethnic rates of cardiovascular disease. Abstract : Supplemental Digital Content is available in the text