GENETIC ASSOCIATION BETWEEN ARTERIAL STIFFNESS–RELATED GENE POLYMORPHISMS IN BRVO AND CRVO PATIENTS IN A TURKISH POPULATION. Issue 10 (October 2015)

• Record Type: Journal Article
• Authors: Demir, Selim; Ortak, Hüseyin; Benli, İsmail; Alim, Sait; Bütün, İlknur; GüneŞ, Alper; AteŞ, Ömer
• Is Part Of: Retina. Volume 35:Issue 10(2015:Oct.)
• Publication Date: 2015-10
• Subjects: branch retinal vein occlusion -- single-nucleotide polymorphism -- adiponectin +276 G/T -- ACE I/D -- AGTR1 A1166C -- eNOS E298D -- p22phox −242 C/T; Retina -- Diseases -- Periodicals; Retinal Diseases; Vitreous Body; 617.735
• DOI: 10.1097/IAE.0000000000000580
• Languages: English
• ISSNs: 0275-004X

Abstract

Abstract : Purpose: To investigate possible associations between five different single-nucleotide polymorphisms, from genes associated with arterial stiffness and branch retinal vein occlusion (BRVO), or central retinal vein occlusion. Methods: A total of 187 patients with retinal vein occlusion (133 with BRVO and 54 with central retinal vein occlusion), and 167 controls, were enrolled in this study. All subjects were screened for hypertension, diabetes, smoking status, body mass index, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, total cholesterol, and very low-density lipoprotein. The genotyping of adiponectin +276 G/T, ACE I/D, AGTR1 A1166C, eNOS E298D, and p22phox −242 C/T polymorphisms was performed using real-time polymerase chain reaction. Results: The percentage of the adiponectin +275 T allele carriers was significantly higher in the BRVO patients (37%) than in the controls (23%, P < 0.001). Similarly, the percentage of AGTR1 1166 C allele carriers was significantly higher in the BRVO patients (38%) than in the controls (24%, P < 0.001). At the multiple logistic regression analysis, the adiponectin +275 T allele carrier and AGTR1 1166 C allele carrier status were found to be associated with an increased risk of BRVO (TT vs. GG and TG: odds ratio = 2.278, P = 0.002, 95% confidence interval: 1.370–3.789; CC vs. AA and AC: odds ratio = 1.804, P = 0.025, 95% confidence interval: 1.079–3.017). The genotype distributions or allelic frequencies of ACE I/D, eNOS E298D, and p22phox −242 C/T did not significantly differ between the patients with BRVO and the control subjects. There was no significant difference between the central retinal vein occlusion patients and controls for the genotype or the allele frequency distributions of all evaluated single-nucleotide polymorphisms. Conclusion: Adiponectin +276 G/T and AGTR1 A1166C single-nucleotide polymorphism are likely to be risk factors for BRVO. Abstract : Although the precise etiology of branch retinal vein occlusion (BRVO) remains unclear, it typically occurs at the arteriovenous crossings where the artery and vein share a common adventitial sheath, and where the thickened artery is supposed to exert compression onto the vein, leading to turbulence downstream in the venous flow, endothelial damage, and sometimes secondary thrombosis. It is shown in the literature that arterial stiffness play a role in the onset or progression of BRVO. Therefore, this article was aimed to investigate the possible association between five different arterial stiffness–related polymorphisms and retinal vein occlusion.