Prostate-Type Adenocarcinoma in Mature Cystic Ovarian Teratoma. (March 2016)

• Record Type: Journal Article
• Authors: Stanhiser, Jamie; Mahdi, Haider; Rosa, Gabriela; Harper, Holly; Shepard, Dale; Rose, Peter G.; Roma, Andres A.
• Is Part Of: International journal of gynecological pathology. Volume 35:Number 2(2016)
• Publication Date: 2016-03
• Subjects: Mature cystic teratoma -- Prostate adenocarcinoma -- NKX3.1 -- PSA -- Gleason score -- Skene's gland adenocarcinoma; Gynecologic pathology -- Periodicals; Gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.10705
• DOI: 10.1097/PGP.0000000000000217
• Languages: English
• ISSNs: 0277-1691

Abstract

Abstract : We report our experience with prostatic-type tissue in ovarian teratomas, and in particular we highlight a case of prostatic-type adenocarcinoma arising within a mature cystic ovarian teratoma in a 32-yr-old woman. On gross examination, the cyst consisted of typical features of a dermoid cyst. Closer examination revealed a single 1.5-cm solid nodule within the cyst. Microscopically, it was composed of a small cyst-like structure lined by urothelium and to one side glandular and stromal tissue consistent with prostate parenchyma. Within the prostatic-type tissue, there were malignant glands morphologically and immunohistochemically supportive of prostatic-type adenocarcinoma Gleason score 3+3=6. There were also areas consistent with high-grade prostatic intraepithelial neoplasia. Although there are several reports in the literature of benign prostatic-type tissue arising within ovarian as well as testicular teratomas, to our knowledge, prostatic-type adenocarcinoma arising in a mature ovarian teratoma is an extremely rare phenomenon, with only 1 previous report in the literature.