THE INFLUENCE OF VITREOMACULAR ADHESION ON OUTCOMES AFTER AFLIBERCEPT THERAPY FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION. Issue 10 (October 2015)

• Record Type: Journal Article
• Authors: McKibbin, Martin A.; Suter, Carlo A.; Willis, Thomas A.
• Is Part Of: Retina. Volume 35:Issue 10(2015:Oct.)
• Publication Date: 2015-10
• Subjects: vitreomacular attachment -- posterior vitreous detachment -- aflibercept -- age-related macular degeneration; Retina -- Diseases -- Periodicals; Retinal Diseases; Vitreous Body; 617.735
• DOI: 10.1097/IAE.0000000000000587
• Languages: English
• ISSNs: 0275-004X

Abstract

Abstract : Purpose: To evaluate the influence of vitreomacular attachment on outcomes after intravitreal aflibercept for neovascular age-related macular degeneration. Methods: In a prospective case series, eyes with neovascular age-related macular degeneration were treated with intravitreal aflibercept, given as 3 consecutive monthly injections, followed by further injection every 2 months. Spectral domain optical coherence tomography images were reviewed at each visit to determine the attachment of the posterior hyaloid. Best-corrected visual acuity and retinal thickness were also recorded. Outcomes at Months 2 and 6 were compared between the eyes with persistent vitreomacular attachment (Stage 1) and those with posterior vitreous detachment (Stages 2 or 3 PVD) at baseline. Results: At baseline, 30 eyes had Stage 1 PVD and 63 eyes had either Stage 2 or 3 PVD. Although there was a trend for both greater visual acuity gains and reductions in retinal thickness for the eyes with Stages 2 or 3 PVD, this failed to reach significance. Baseline visual acuity and age were negatively associated with visual acuity change, and baseline retinal thickness alone was associated with retinal thickness change. Conclusion: Visual acuity, retinal thickness, and age at the baseline examination, but not PVD status, are associated with functional and anatomical outcomes after intravitreal aflibercept for neovascular age-related macular degeneration. Abstract : Although separation of the posterior hyaloid from the macula was associated with better anatomical and functional outcomes after intravitreal aflibercept for neovascular age-related macular degeneration when compared with eyes with persistent attachment, this failed to reach statistical significance.