Fetal vascular adaptation before and after treatment of severe maternal anemia in pregnancy. Issue 3 (17th February 2016)

• Record Type: Journal Article
• Authors: Ali, Eram; Kumar, Manisha; Naqvi, Sayyed E.H.; Trivedi, Shubha S.; Singh, Anuradha
• Is Part Of: International journal of gynaecology and obstetrics. Volume 133:Issue 3(2016:Jun.)
• Page Start: 284
• Page End: 286
• Publication Date: 2016-02-17
• Subjects: Cerebral/umbilical resistance ratio -- Doppler velocimetry -- Maternal anemia -- Middle cerebral artery -- Peak systolic velocity -- Pulsatility index -- Resistance index -- Systolic/diastolic ratio -- Umbilical artery; Gynecology -- Periodicals; Obstetrics -- Periodicals; Electronic journals; 618
• DOI: 10.1016/j.ijgo.2015.11.011
• Languages: English
• ISSNs: 0020-7292

Abstract

Abstract: Objectives: To use color Doppler ultrasonography indices to study the effects on fetal circulation of treating severe maternal anemia. Methods: A prospective cohort study enrolled patients who were at 30–34 weeks of pregnancy and had hemoglobin levels below 70 g/L between November 1, 2011 and March 31, 2013 at a hospital in New Delhi, India. A control group consisting of patients with the same duration of pregnancy and with hemoglobin levels above 110 g/L was included. Umbilical artery and middle cerebral artery velocimetry were performed using color Doppler ultrasonography at admission and after 4 weeks and 6 weeks of treatment. Results: The maternal anemia cohort demonstrated a significantly lower middle cerebral artery resistance index and middle cerebral/umbilical artery resistance ratio ( P < 0.001) at admission. Following 4 weeks of treatment for maternal anemia, significant increases in these parameters were observed ( P < 0.001). Conclusion: Fetuses of individuals with severe maternal anemia demonstrated altered cerebral and umbilical artery flows. Normal flows were restored following treatment of maternal anemia.