5-HT2A and mGlu2/3 receptor interactions: on their relevance to cognitive function and psychosis. Issue 1 (February 2016)

• Record Type: Journal Article
• Authors: Wischhof, Lena; Koch, Michael
• Is Part Of: Behavioural pharmacology. Volume 27:Issue 1(2016)
• Publication Date: 2016-02
• Subjects: antipsychotic drugs -- behavioral function -- glutamate -- hallucinogens -- receptor interactions -- schizophrenia -- serotonin; Psychopharmacology -- Periodicals; Nervous System -- drug effects -- Periodicals; Behavior -- drug effects -- Periodicals; 615.78
• DOI: 10.1097/FBP.0000000000000183
• Languages: English
• ISSNs: 0955-8810

Abstract

Abstract : Serotonin [5-hydroxytryptamine (5-HT)] and glutamate have both been implicated in the pathophysiology of neuropsychiatric disorders but also in the mechanism of antipsychotic and hallucinogenic drug actions. Furthermore, close antagonistic interactions between 5-HT2A and metabotropic glutamate (mGlu)2/3 receptors have been established over the last decades on the basis of numerous electrophysiological, biochemical, and behavioral studies. Besides synaptic mechanisms, more recent findings suggested that heterodimeric 5-HT2A –mGlu2 receptor complexes in the prefrontal cortex may account for the functional crosstalk between these two receptor subtypes. In this review, we focus on in-vitro and in-vivo studies documenting the important relationship between 5-HT2A and mGlu2/3 receptors, with relevance to both normal behavioral function and psychosis.