Tenofovir Disoproxil Fumarate Intravaginal Ring Protects High-Dose Depot Medroxyprogesterone Acetate–Treated Macaques From Multiple SHIV Exposures. (1st January 2015)

• Record Type: Journal Article
• Authors: Smith, James M.; Srinivasan, Priya; Teller, Ryan S.; Lo, Yungtai; Dinh, Chuong T.; Kiser, Patrick F.; Herold, Betsy C.
• Is Part Of: Journal of acquired immune deficiency syndromes. Volume 68:Number 1(2015)
• Publication Date: 2015-01-01
• Subjects: macaque -- intravaginal ring -- TDF -- Depo-Provera -- PrEP; AIDS (Disease) -- Periodicals; Acquired Immunodeficiency Syndrome -- Periodicals; AIDS (Disease); Periodicals; 616.9792005
• DOI: 10.1097/QAI.0000000000000402
• Languages: English
• ISSNs: 1525-4135

Abstract

Abstract : Abstract: Preclinical HIV prevention models use either a single high-dose viral challenge in depot medroxyprogesterone acetate–treated macaques or repeated viral challenges in cycling macaques. We tested the efficacy of an intravaginal tenofovir disoproxil fumarate (TDF) ring in a model combining repeated 30-mg injections of depot medroxyprogesterone acetate every 6 weeks with vaginal viral challenges weekly for 12 weeks. Twelve macaques were randomized to TDF or placebo rings. All placebo macaques became infected after a median of 2 exposures, whereas only 1 TDF macaque became infected at the eighth exposure ( P = 0.0012). The TDF ring provides durable protection in a stringent challenge model. Abstract : Supplemental Digital Content is Available in the Text.