Α-Glucosidase inhibition by flavonoids: an in vitro and in silico structure–activity relationship study. (1st January 2017)

• Record Type: Journal Article
• Authors: Proença, Carina; Freitas, Marisa; Ribeiro, Daniela; Oliveira, Eduardo F. T.; Sousa, Joana L. C.; Tomé, Sara M.; Ramos, Maria J.; Silva, Artur M. S.; Fernandes, Pedro A.; Fernandes, Eduarda
• Is Part Of: Journal of enzyme inhibition and medicinal chemistry. Volume 32:Number 1(2017)
• Page Start: 1216
• Page End: 1228
• Publication Date: 2017-01-01
• Subjects: Diabetes -- flavonoids -- α-glucosidase inhibition -- in vitro -- in silico; Enzyme inhibitors -- Periodicals; Enzyme Inhibitors -- periodicals; Biochemistry -- periodicals; 572.7
• DOI: 10.1080/14756366.2017.1368503
• Languages: English
• ISSNs: 1475-6366

Abstract

Abstract: α-Glucosidase inhibitors are described as the most effective in reducing post-prandial hyperglycaemia (PPHG) from all available anti-diabetic drugs used in the management of type 2 diabetes mellitus . As flavonoids are promising modulators of this enzyme's activity, a panel of 44 flavonoids, organised in five groups, was screened for their inhibitory activity of α-glucosidase, based on in vitro structure–activity relationship studies. Inhibitory kinetic analysis and molecular docking calculations were also applied for selected compounds. A flavonoid with two catechol groups in A- and B-rings, together with a 3-OH group at C-ring, was the most active, presenting an IC50 much lower than the one found for the most widely prescribed α-glucosidase inhibitor, acarbose . The present work suggests that several of the studied flavonoids have the potential to be used as alternatives for the regulation of PPHG. Graphical Abstract: