Brief Report: Prevalence of Latent Rheumatic Heart Disease Among HIV-Infected Children in Kampala, Uganda. (1st February 2016)

• Record Type: Journal Article
• Authors: Gleason, Brigette; Mirembe, Grace; Namuyonga, Judith; Okello, Emmy; Lwabi, Peter; Lubega, Irene; Lubega, Sulaiman; Musiime, Victor; Kityo, Cissy; Salata, Robert A.; Longenecker, Chris T.
• Is Part Of: Journal of acquired immune deficiency syndromes. Volume 71:Number 2(2016)
• Publication Date: 2016-02-01
• Subjects: rheumatic heart disease -- HIV/AIDS -- echocardiogram -- cotrimoxazole; AIDS (Disease) -- Periodicals; Acquired Immunodeficiency Syndrome -- Periodicals; AIDS (Disease); Periodicals; 616.9792005
• DOI: 10.1097/QAI.0000000000000827
• Languages: English
• ISSNs: 1525-4135

Abstract

Abstract : Abstract: Rheumatic heart disease (RHD) remains highly prevalent in resource-constrained settings around the world, including countries with high rates of HIV/AIDS. Although both are immune-mediated diseases, it is unknown whether HIV modifies the risk or progression of RHD. We performed screening echocardiography to determine the prevalence of latent RHD in 488 HIV-infected children aged 5–18 in Kampala, Uganda. The overall prevalence of borderline/definite RHD was 0.82% (95% confidence interval: 0.26% to 2.23%), which is lower than the published prevalence rates of 1.5%–4% among Ugandan children. There may be protective factors that decrease the risk of RHD in HIV-infected children. Abstract : Supplemental Digital Content is Available in the Text.