Development and evaluation of olmesartan medoxomil loaded PLGA nanoparticles. (15th April 2016)

• Record Type: Journal Article
• Authors: Anwer, M. K.; Jamil, S.; Ansari, M. J.; Iqbal, M.; Imam, F.; Shakeel, F.
• Is Part Of: Materials research innovations. Volume 20:Number 3(2016)
• Page Start: 193
• Page End: 197
• Publication Date: 2016-04-15
• Subjects: Polymer -- Nanoparticle -- Particle size -- Drug entrapment -- Olmesartan medoxomil -- SEM; Materials -- Research -- Periodicals; Matériaux -- Recherche -- Périodiques; 620.1105
• DOI: 10.1179/1433075X15Y.0000000049
• Languages: English
• ISSNs: 1432-8917

Abstract

Abstract : The purpose of the present study was to develop olmesartan medoxomil (OLM) loaded poly (d, l -lactide-co-glycolide) (PLGA) nanoparticles by nanoprecipitation technique. Olmesartan medoxomil nanoparticles (F1–F3) were prepared using PLGA as polymer and Pluronic acid 127 as a surfactant. Developed PLGA nanoparticles were evaluated for particle size, polydispersity index (PI), differential scanning calorimetry (DSC), Fourier transforms infrared (FTIR) spectroscopy, powder X-ray diffraction (XRD), scanning electron microscopy (SEM), drug entrapment efficiency (EE%) and in vitro drug release. Optimised PLGA nanoparticle (F3) had particle size of 97.8 ± 6.3 nm, EE of 58.33% and drug release of 37.1% after 24 h of study. SEM images confirmed that developed nanoparticles were spherical in shape with a smooth surface. DSC, FTIR, and XRD spectra indicated formation of PLGA nanoparticles. The results suggest that PLGA polymer-based nanoparticle could be a potential option for sustained drug delivery of OLM.