Expression of Epithelial-Mesenchymal Transition-related Factors in Adherent Placenta. (November 2015)

• Record Type: Journal Article
• Authors: Shirakawa, Tokuro; Miyahara, Yoshiya; Tanimura, Kenji; Morita, Hiroki; Kawakami, Fumi; Itoh, Tomoo; Yamada, Hideto
• Is Part Of: International journal of gynecological pathology. Volume 34:Number 6(2015:Nov.)
• Publication Date: 2015-11
• Subjects: Adherent placenta -- E-cadherin -- Snail -- TGF-β; Gynecologic pathology -- Periodicals; Gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.10705
• DOI: 10.1097/PGP.0000000000000190
• Languages: English
• ISSNs: 0277-1691

Abstract

Abstract : Epithelial-mesenchymal transition is a key process influencing cancer progression and metastasis. The purpose of this study was to investigate the expression of epithelial-mesenchymal transition-related factors in chorionic villi and decidual cells in adherent placenta. The current study included 19 patients diagnosed with adherent placenta after hysterectomy. The expression of E-cadherin, Vimentin, Snail, and transforming growth factor-β in placental tissues was analyzed by immunohistochemical staining. Immunostaining intensity was semiquantitatively evaluated using the HSCORE algorithm. In the chorionic villi of the invasive part (placenta with invasion into myometrium), E-cadherin expression was significantly lower than that in the noninvasive part (placenta with no invasion). In the decidual cells of the invasive part, expression of transforming growth factor-β and Snail significantly increased. These results suggest that epithelial-mesenchymal transition may contribute to excessive trophoblast invasion into the myometrium in adherent placenta.