An Expanded Spectrum of High-Grade B-Cell Non-Hodgkin Lymphomas Involving the Cervicovaginal Region. (November 2015)

• Record Type: Journal Article
• Authors: Pather, Sugeshnee; Philip, Vinitha; Lakha, Atul B.; Wiggill, Tracey M.; Suleman, Marie; Patel, Moosa
• Is Part Of: International journal of gynecological pathology. Volume 34:Number 6(2015:Nov.)
• Publication Date: 2015-11
• Subjects: Lymphoma -- Cervix -- Vagina; Gynecologic pathology -- Periodicals; Gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.10705
• DOI: 10.1097/PGP.0000000000000220
• Languages: English
• ISSNs: 0277-1691

Abstract

Abstract : The uterine cervix and vaginal regions are infrequently infiltrated by lymphoma. Involvement of these topographic regions may constitute primary disease or more commonly represent a manifestation of systemic lymphomatous disease. Herein, we report an expanded spectrum of high-grade B-cell non-Hodgkin lymphomas comprising plasmablastic lymphoma (with and without plasmacytic differentiation), ALK-positive large B-cell lymphoma, and diffuse large B-cell lymphoma which involved the uterine cervix and/or vagina of 6 patients at initial diagnosis. These tumors clinically mimicked carcinoma and developed predominantly, but not exclusively, in the setting of human immunodeficiency virus infection.