P-082 YI Predictors of Health Related Quality of Life in Microscopic Colitis. (March 2016)

• Record Type: Journal Article
• Authors: Dosanjh, Grace; Tremaine, William; Loftus, Edward; Kammer, Patricia; Harmsen, W. Scott; Pardi, Darrell
• Is Part Of: Inflammatory bowel diseases. Volume 22(2016:Mar.)Supplement 1
• Publication Date: 2016-03
• Subjects: Inflammatory bowel diseases -- Periodicals; Colitis, Ulcerative -- Periodicals; Crohn Disease -- Periodicals; Inflammatory Bowel Diseases -- Periodicals; 616.344
• DOI: 10.1097/01.MIB.0000480176.28038.eb
• Languages: English
• ISSNs: 1078-0998

Abstract

Abstract : Background: Health related quality of life (HRQOL) in patients with Microscopic Colitis (MC) is poor. We sought to identify clinical features that predict HRQOL. Methods: Outpatients with MC were asked to complete a symptom questionnaire and a HRQOL questionnaire, the Inflammatory Bowel Disease Questionnaire (IBDQ). The IBDQ was utilized since MC-specific validated tools do not exist. Lower IBDQ scores indicate a worse HRQOL. For statistical analysis, 2 sample t test was used to compare continuous variables and χ 2 test (or Fisher's Exact Test where appropriate) was used to compare proportions. Multiple variable logistic regression modeling was used to calculate odds ratios where appropriate and identify variables independently associated with HRQOL. Results: One hundred thirty-four patients were included (49% CC and 51% LC) with median ages of 61.7 and 67.8 years, respectively. 54% of CC patients were female as compared to 46% of LC patients. The median IBDQ score was 149. In a multivariate analysis, the presence of abdominal pain ( P = 0.0004), weight loss ( P = 0.0074), age at diagnosis ( P = 0.0035), and number of stools per day ( P = 0.0004) were predictors of baseline HRQOL but gender ( P = 0.33), nocturnal bowel movements ( P = 0.38), urgency ( P = 0.96) and number of incontinence episodes per month ( P = 0.18) were not. Abdominal pain had the strongest negative correlation with baseline IBDQ scores. Age was the only variable studied that had a positive correlation with HRQOL (indicating that older age at diagnosis was associated with higher HRQOL), but this was not a strong relationship. We also evaluated HRQOL by subtype of microscopic colitis to see if similar relationships exist. The presence of abdominal pain and numbers of stools per day were predictors of baseline HRQOL for both LC and CC, but weight loss and age at diagnosis were only predictors of HRQOL in LC ( P = 0.0005, P = 0.013) but not CC ( P = 0.72, P = 0.16). Conclusions: HRQOL is impaired in patients with microscopic colitis in a range reported previously for IBD. In multivariate analysis, the presence of abdominal pain, weight loss, age at diagnosis and the number of stools per day were predictors of baseline HRQOL. Abdominal pain was noted to have the strongest negative relationship with HRQOL. Abdominal pain and weight loss should be considered as outcome measures in future treatment trials in MC. HRQOL was impaired to a similar degree in patients with LC and CC, although the predictors of HRQOL varied between these subtypes.