Antagonistic role of natural compounds in mTOR-mediated metabolic reprogramming. Issue 2 (28th January 2015)

• Record Type: Journal Article
• Authors: Cerella, Claudia; Gaigneaux, Anthoula; Dicato, Mario; Diederich, Marc
• Is Part Of: Cancer letters. Volume 356:Issue 2(2015)Part A
• Page Start: 251
• Page End: 262
• Publication Date: 2015-01-28
• Subjects: AMPK AMP-activated protein kinase -- EGCG epigallocatechin-3-gallate -- CG cardiac glycoside -- 4E-BP eukaryotic initiation factor 4E (eIF4E)-binding protein -- FAS fatty acid synthase -- FoxO forkhead box O -- GLUT glucose transporter -- HK2 hexokinase-2 -- HIF-1α hypoxia-inducible factor 1 alpha -- HDAC histone deacetylase -- IKK IκB kinase -- IRES internal ribosomal entry sites -- mTOR mammalian target of rapamycin -- MDM-2 murine double minute 2 -- mTORC mTOR complex -- NF-κB nuclear factor-κB -- PPP pentose phosphate pathway -- PTEN phosphatase and tensin homolog deleted on chromosome 10 -- PI3K phosphatidylinositol-3-kinase -- PFK1 phosphofructokinase-1 -- PKCα protein kinase alpha -- Rheb Ras homolog enriched in brain -- Rag Ras-related GTPase -- S6K ribosomal S6 kinase -- SGK serum- and glucocorticoid-induced protein kinase -- SREBP sterol regulatory element-binding proteins -- TSC tuberous sclerosis complex; Cancer -- Metabolism -- Natural compounds -- mTOR; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2014.02.008
• Languages: English
• ISSNs: 0304-3835

Abstract

Abstract: Cells reprogram their metabolism very early during carcinogenesis; this event is critical for the establishment of other cancer hallmarks. Many oncogenes and tumor suppressor genes control metabolism by interplaying with the existing nutrient-sensing intracellular pathways. Mammalian target of rapamycin, mTOR, is emerging as a collector and sorter of a metabolic network controlling upstream and downstream modulation of these same genes. Natural compounds represent a source of anti-cancer molecules with chemopreventive and therapeutic properties. This review describes selected pathways and genes orchestrating the metabolic reprogramming and discusses the potential of natural compounds to target oncogenic metabolic aberrations.