Higher Body Mass Index Is Associated With Greater Proportions of Effector CD8+ T Cells Expressing CD57 in Women Living With HIV. (15th August 2017)

• Record Type: Journal Article
• Authors: Reid, Michael J. A.; Baxi, Sanjiv M.; Sheira, Lila A.; Landay, Alan L.; Frongillo, Edward A.; Adedimeji, Adebola; Cohen, Mardge H.; Wentz, Eryka; Gustafson, Deborah R.; Merenstein, Daniel; Hunt, Peter W.; Tien, Phyllis C.; Weiser, Sheri D.
• Is Part Of: Journal of acquired immune deficiency syndromes. Volume 75:Number 5(2018)
• Publication Date: 2017-08-15
• Subjects: HIV -- obesity -- WIHS -- CD57 -- immune senescence; AIDS (Disease) -- Periodicals; Acquired Immunodeficiency Syndrome -- Periodicals; AIDS (Disease); Periodicals; 616.9792005
• DOI: 10.1097/QAI.0000000000001376
• Languages: English
• ISSNs: 1525-4135

Abstract

Abstract : Background: A low proportion of CD28 − CD8 + T cells that express CD57 is associated with increased mortality in HIV infection. The effect of increasing body mass index (BMI) changes in the proportion of CD57 + CD28 − CD8 + T cells among HIV-infected individuals on antiretroviral therapy is unknown. Setting: In a US cohort of HIV-infected women, we evaluated associations of BMI and waist circumference with 3 distinct CD8 + T cell phenotypes: % CD28 − CD57 + CD8 + T cells, % CD57 + of CD28 − CD8 + T cells, and % CD28 − of all CD8 + T cells. Methods: Multivariable linear regression analysis was used to estimate beta coefficients for each of 3 T-cell phenotypes. Covariates included HIV parameters (current and nadir CD4, current viral load), demographics (age, race, income, and study site), and lifestyle (tobacco and alcohol use) factors. Results: Of 225 participants, the median age was 46 years and 50% were obese (BMI >30 m 2 /kg). Greater BMI and waist circumference were both associated with higher % CD28 − CD57 + CD8 + T cells and % CD57 + of all CD28 − CD8 + T cells in multivariable analysis, including adjustment for HIV viral load (all P < 0.05). The association between greater BMI and the overall proportion of CD28 − CD8 + cells in fully adjusted models (0.078, 95% confidence interval: −0.053 to 0.209) was not significant. Conclusions: In this analysis, greater BMI and waist circumference are associated with greater expression of CD57 on CD28 − CD8 + T cells and a greater proportion of CD57 + CD28 − CD8 + T cells. These findings may indicate that increasing BMI is immunologically protective in HIV-infected women. Future research is needed to understand the prognostic importance of these associations on clinical outcomes.