Crooke's Cell Tumors of the Pituitary. Issue 5 (May 2015)

• Record Type: Journal Article
• Authors: Di Ieva, Antonio; Davidson, Jennilee M.; Syro, Luis V.; Rotondo, Fabio; Montoya, Julian F.; Horvath, Eva; Cusimano, Michael D.; Kovacs, Kalman
• Is Part Of: Neurosurgery. Volume 76:Issue 5(2015)
• Publication Date: 2015-05
• Subjects: Adrenocorticotropic hormone producing pituitary tumor -- Aggressive pituitary adenoma -- Crooke's cell -- Hyalinization -- Pituitary adenoma -- Pituitary carcinoma; Nervous system -- Surgery -- Periodicals; 617.48005
• DOI: 10.1227/NEU.0000000000000657
• Languages: English
• ISSNs: 0148-396X

Abstract

Abstract : Crooke's cell adenomas are a rare type of pituitary neoplasm. They produce adrenocorticotropic hormone causing Cushing's disease or may be endocrinologically silent. These tumors are usually invasive, may exhibit aggressive clinical behavior, and often recur with a low success of cure after reoperation and/or radiotherapy. Due to their rarity, they present great difficulties in assessing prognosis, treatment, and clinical management. Neurosurgeons and physicians dealing with pituitary adenomas diagnosed as Crooke's cell adenomas have to be aware of their potential clinical aggressiveness to plan strict follow-up of patients and eventual multimodality treatment. We review here the published cases of Crooke's cell tumors, as well as the clinical and histopathological characteristics of these unusual neoplasms. ABBREVIATIONS: ACTH, adrenocorticotropic hormone CCA, Crooke's cell adenoma CK, cytokeratin PAS, periodic acid–Schiff TMZ, temozolomide