Anti-CD73 immunotherapy: A viable way to reprogram the tumor microenvironment. (1st September 2016)

• Record Type: Journal Article
• Authors: Antonioli, Luca; Blandizzi, Corrado; Malavasi, Fabio; Ferrari, Davide; Haskó, György
• Is Part Of: Oncoimmunology. Volume 5:Number 9(2016)
• Publication Date: 2016-09-01
• Subjects: CD73 -- monoclonal antibody -- tumor microenvironment -- immunotherapy -- autophagy; Tumors -- Immunological aspects -- Periodicals; Neoplasms -- therapy -- Periodicals; Immunotherapy -- Periodicals; 616.994
• DOI: 10.1080/2162402X.2016.1216292
• Languages: English
• ISSNs: 2162-402X

Abstract

Abstract: The ecto-5'-nucleotidase/CD73 enzyme plays a pivotal role in generating an adenosine-enriched immunosuppressed and pro-angiogenic niche supporting cancer development. The targeting of CD73 leads to reorganization of tumor microenvironment, shaping the phenotype of the infiltrating T cells. The development of CD73 monoclonal antibodies offers a promising new avenue for antineoplastic treatment.