Utility of Applying Quality Assessment Tools for Kidneys With KDPI ≥80. Issue 6 (June 2017)

• Record Type: Journal Article
• Authors: Doshi, Mona D.; Reese, Peter P.; Hall, Isaac E.; Schröppel, Bernd; Ficek, Joseph; Formica, Richard N.; Weng, Francis L.; Hasz, Rick D.; Thiessen-Philbrook, Heather; Parikh, Chirag R.
• Is Part Of: Transplantation. Volume 101:Issue 6(2017)
• Publication Date: 2017-06
• Subjects: Transplantation of organs, tissues, etc -- Periodicals; Transplantation immunology -- Periodicals; 617.95
• DOI: 10.1097/TP.0000000000001388
• Languages: English
• ISSNs: 0041-1337

Abstract

Abstract : Background: Kidneys with "high" Kidney Donor Profile Index (KDPI) are often biopsied and pumped, yet frequently discarded. Methods: In this multicenter study, we describe the characteristics and outcomes of kidneys with KDPI of 80 or greater that were procured from 338 deceased donors. We excluded donors with anatomical kidney abnormalities. Results: Donors were categorized by the number of kidneys discarded: (1) none (n = 154, 46%), (2) 1 discarded and 1 transplanted (n = 48, 14%), (3) both discarded (n = 136, 40%). Donors in group 3 were older, more often white, and had higher terminal creatinine and KDPI than group 1 (all P < 0.05). Biopsy was performed in 92% of all kidneys, and 47% were pumped. Discard was associated with biopsy findings and first hour renal resistance. Kidney injury biomarker levels (neutrophil gelatinase-associated lipocalin, IL-18, and kidney injury molecule-1 measured from donor urine at procurement and from perfusate soon after pump perfusion) were not different between groups. There was no significant difference in 1-year estimated glomerular filtration rate or graft failure between groups 1 and 2 (41.5 ± 18 vs 41.4 ± 22 mL/min per 1.73 m 2 ; P = 0.97 and 9% vs 10%; P = 0.76). Conclusions: Kidneys with KDPI of 80 or greater comprise the most resource consuming fraction of our donor kidney pool and have the highest rates of discard. Our data suggest that some discarded kidneys with KDPI of 80 or greater are viable; however, current tools and urine and perfusate biomarkers to identify these viable kidneys are not satisfactory. We need better methods to assess viability of kidneys with high KDPI. Abstract : The authors evaluate the fate of >80 KDPI kidneys and the factors explaining the discard rate which is known to be the highest in this category of donors. They show that some of these kidneys are viable but that current factors (biopsy, machine perfusion use, urine biomarkers) used to choose to discard or not are not discriminant enough. Supplemental digital content is available in the text.