Epidemiology of Human Papillomavirus Detected in the Oral Cavity and Fingernails of Mid-Adult Women. Issue 12 (December 2015)

• Record Type: Journal Article
• Authors: Fu, Tsung-chieh (Jane); Hughes, James P.; Feng, Qinghua; Hulbert, Ayaka; Hawes, Stephen E.; Xi, Long Fu; Schwartz, Stephen M.; Stern, Joshua E.; Koutsky, Laura A.; Winer, Rachel L.
• Is Part Of: Sexually transmitted diseases. Volume 42:Issue 12(2015)
• Publication Date: 2015-12
• Subjects: Sexually transmitted diseases -- Periodicals; Sexual health -- Periodicals; 616.951005
• DOI: 10.1097/OLQ.0000000000000362
• Languages: English
• ISSNs: 0148-5717

Abstract

Abstract : Background: Oral and fingernail human papillomavirus (HPV) detection may be associated with HPV-related carcinoma risk at these nongenital sites and foster transmission to the genitals. We describe the epidemiology of oral and fingernail HPV among mid-adult women. Methods: Between 2011 and 2012, 409 women aged 30 to 50 years were followed up for 6 months. Women completed health and behavior surveys and provided self-collected oral, fingernail, and vaginal specimens at enrollment and exit for type-specific HPV DNA testing. Concordance of type-specific HPV detection across anatomical sites was described with κ statistics. Using generalized estimating equations or exact logistic regression, we measured the univariate associations of various risk factors with type-specific oral and fingernail HPV detection. Results: Prevalence of detecting HPV in the oral cavity (2.4%) and fingernails (3.8%) was low compared with the vagina (33.1%). Concordance across anatomical sites was poor ( κ < 0.20 for all comparisons). However, concurrent vaginal infection with the same HPV type (odds ratio [OR], 101.0; 95% confidence interval [CI], 31.4–748.6) and vaginal HPV viral load (OR per 1 log10 viral load increase, 2.2; 95% CI, 1.5–5.5) were each associated with fingernail HPV detection. Abnormal Papanicolaou history (OR, 11.1; 95% CI, 2.8–infinity), lifetime number of male vaginal sex partners at least 10 (OR vs. 0–3 partners, 5.0; 95% CI, 1.2–infinity), and lifetime number of open-mouth kissing partners at least 16 (OR vs. 0–15 partners, infinity; 95% CI, 2.6–infinity, by exact logistic regression) were each associated with oral HPV detection. Conclusions: Although our findings support HPV DNA deposition or autoinoculation between anatomical sites in mid-adult women, the rarity of HPV in the oral cavity and fingernails suggests that oral/fingernail HPV does not account for a significant fraction of HPV in genital sites. Abstract : Among mid-adult women, oral human papillomavirus (HPV) was associated with abnormal Papanicolaou history and lifetime numbers of kissing and male vaginal sex partners; fingernail HPV was associated with concurrent type-specific vaginal HPV.