SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY FINDINGS IN LONG-TERM SILICONE OIL–RELATED VISUAL LOSS. Issue 3 (March 2015)

• Record Type: Journal Article
• Authors: Shalchi, Zaid; Mahroo, Omar A.; Shunmugam, Manoharan; Mohamed, Moin; Sullivan, Paul M.; Williamson, Tom H.
• Is Part Of: Retina. Volume 35:Issue 3(2015:Mar.)
• Publication Date: 2015-03
• Subjects: microcystic macular changes -- microcystic macular edema -- optic neuropathy -- optical coherence tomography -- phototoxicity -- silicone oil -- vision loss -- visual loss; Retina -- Diseases -- Periodicals; Retinal Diseases; Vitreous Body; 617.735
• DOI: 10.1097/IAE.0000000000000325
• Languages: English
• ISSNs: 0275-004X

Abstract

Abstract : Purpose: To investigate spectral domain optical coherence tomography findings in long-term silicone oil–related visual loss. Methods: Four symptomatic patients were reviewed 4 years to 9 years after vitrectomy with silicone oil tamponade for macula-on retinal detachment. Three lost vision with oil in situ, with one at the time of oil removal. Eleven control eyes with good vision were included. Patients underwent assessment of best-corrected visual acuity, contrast sensitivity, Farnsworth-Munsell 100 Hue testing, static perimetry, and spectral domain optical coherence tomography imaging of the macula and disk. Results: Long-term best-corrected visual acuity was significantly reduced in affected eyes (range, 0.44–1.02), as was contrast sensitivity (0.75–1.35) and color discrimination (Farnsworth-Munsell-100 Hue score, 151–390). Static perimetry showed a central scotoma in all affected eyes. Optical coherence tomography revealed microcystic macular changes in the inner nuclear layer of all affected eyes associated with severe loss of the papillofoveal retinal nerve fiber layer. In one patient, serial optical coherence tomography images showed development of microcystic macular changes 18 months after oil removal. Control eyes lacked these features, except two asymptomatic eyes that showed microcystic changes on optical coherence tomography with a corresponding paracentral scotoma. Conclusion: We have demonstrated microcystic macular changes in the inner nuclear layer of affected eyes, as well as focal severe loss of the papillofoveal projection. These changes share significant morphologic features reported in multiple sclerosis–associated optic neuritis and Leber hereditary optic neuropathy. Abstract : Long-term silicone oil–related visual loss is associated with microcystic macular changes in the inner nuclear layer and severe loss of the papillofoveal retinal nerve fiber layer on spectral domain optical coherence tomography imaging.