Post-transplant lymphoproliferative disorder after kidney transplantation: time to adopt monitoring of Epstein-Barr virus?. Issue 3 (June 2015)

• Record Type: Journal Article
• Authors: Biller, P.; Michaux, L.; Pauw, L. De; Camboni, A.; Mourad, M.; Kanaan, N.
• Is Part Of: Acta clinica belgica. Volume 70:Issue 3(2015)
• Page Start: 218
• Page End: 222
• Publication Date: 2015-06
• Subjects: PTLD, -- Lymphoma, -- Transplantation, -- Epstein-Barr virus, -- EBV; Clinical medicine -- Periodicals; Diagnosis, Laboratory -- Periodicals; 616.005
• DOI: 10.1179/2295333714Y.0000000112
• Languages: English
• ISSNs: 1784-3286

Abstract

Abstract : Although post-transplant lymphoproliferative disorder is a classical complication encountered after kidney transplantation, its diagnosis can still be challenging and its outcome life-threatening. Most cases are related to Epstein-Barr virus (EBV) infection and occur mainly in the first year post-transplant, favoured by the seronegative EBV status of the recipient transplanted with a kidney from a seropositive donor, and strong immunosuppression. We report the case of a young kidney-pancreas transplant recipient who developed post-transplant lymphoproliferative disorder (PTLD) early after transplantation, with a rapid fatal issue. We review the pathogenesis, clinical presentation, and management of PTLD with a focus on prevention.