Initial experience of use of tolvaptan in critically ill patients with fluid overload. (6th March 2015)

• Record Type: Journal Article
• Authors: Ruiz‐Ramos, J.; Gordon, M.; Cortes, M. A.; Broch, M. J.; Ramirez, P.
• Is Part Of: Journal of clinical pharmacy and therapeutics. Volume 40:Number 3(2015:Jun.)
• Page Start: 339
• Page End: 341
• Publication Date: 2015-03-06
• Subjects: clinical pharmacy -- drug utilisation -- furosemide; Clinical pharmacology -- Periodicals; Chemotherapy -- Periodicals; 615
• DOI: 10.1111/jcpt.12255
• Languages: English
• ISSNs: 0269-4727

Abstract

Abstract: What is known and objective: Positive volume balance is related with high mortality in critically ill patients. We describe our experience in the use of tolvaptan in patients with fluid overload. Case summary: Six patients in the recovery phase from septic shock were included. All patients achieved an increase in diuresis after the first day, with a median fluid balance variation of −2362 (−485 to −3447) mL. At the end of treatment, median fluid balance variation was −9080 (−26 784 to −4395) mL. What is new and Conclusion: Tolvaptan could be an option in critically ill patients with fluid overload and resistant or not treatable with conventional diuretics.