Imaging Nigrostriatal Dopaminergic Deficit in Holmes Tremor with 18F-PR04.MZ-PET/CT. (September 2015)

• Record Type: Journal Article
• Authors: Juri, Carlos; Chana, Pedro; Kramer, Vasko; Pruzzo, Rossana; Amaral, Horacio; Riss, Patrick J.; Rösch, Frank
• Is Part Of: Clinical nuclear medicine. Volume 40:Number 9(2015)
• Publication Date: 2015-09
• Subjects: 18F -- dopamine transporters -- PET imaging -- Holmes tremor -- movement disorders; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000000868
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: Holmes tremor is an infrequent clinical syndrome characterized by unilateral rest, postural, and action tremor often secondary to a brain lesion. We herein report an interesting case of Holmes tremor studied with PET and 18 F-PR04.MZ, a new high-affinity radioligand for dopamine transporters, currently under investigation at our center. 18 F-PR04.MZ-PET can be useful to study the integrity of the nigrostriatal dopaminergic system to improve diagnosis and therapeutic outcome in patients with Holmes tremor and Parkinson disease.