Pneumococcal Meningitis Vaccine Breakthroughs and Failures After Routine 7-Valent and 13-Valent Pneumococcal Conjugate Vaccination in Children in France. Issue 10 (October 2015)

• Record Type: Journal Article
• Authors: Godot, Cécile; Levy, Corinne; Varon, Emmanuelle; Picard, Capucine; Madhi, Fouad; Cohen, Robert
• Is Part Of: Pediatric infectious disease journal. Volume 34:Issue 10(2015)
• Publication Date: 2015-10
• Subjects: vaccine breakthrough -- vaccine failure -- pneumococcal meningitis -- pneumococcal conjugate vaccine -- children; Communicable diseases in children -- Periodicals; Infection in children -- Periodicals; 618.929
• DOI: 10.1097/INF.0000000000000818
• Languages: English
• ISSNs: 0891-3668

Abstract

Abstract : We collected cases of pneumococcal meningitis vaccine breakthrough (VBT) and vaccine failure (VF) from 2003 to 2013 after the implementation of pneumococcal conjugate vaccines (PCVs) in France. VBT accounted for 3.2% of the cases (PCV7 era: 24 of 943, PCV13 era: 15 of 290) and VF 0.6% (PCV7 era: 6 of 943, PCV13 era: 2 of 290). VBT and VF are rare and occur in most cases in children younger than 2 years. The serotype 19F was the most frequent cause even after the introduction of PCV13. Abstract : Supplemental Digital Content is available in the text.