Antimicrobial properties and dental pulp stem cell cytotoxicity using carboxymethyl cellulose-silver nanoparticles deposited on titanium plates. Issue 1 (1st January 2016)

• Record Type: Journal Article
• Authors: Laredo-Naranjo, Martha Alicia; Carrillo-Gonzalez, Roberto; De La Garza-Ramos, Myriam Angelica; Garza-Navarro, Marco Antonio; Torre-Martinez, Hilda H. H.; Del Angel-Mosqueda, Casiano; Mercado-Hernandez, Roberto; Carrillo-Fuentevilla, Roberto
• Is Part Of: Acta biomaterialia odontologica Scandinavica. Volume 2:Issue 1(2016)
• Page Start: 60
• Page End: 67
• Publication Date: 2016-01-01
• Subjects: Antibacterial activity -- dental pulp stem cells -- orthodontics
• DOI: 10.3109/23337931.2016.1160783
• Languages: English
• ISSNs: 2333-7931

Abstract

Abstract: Objective: To evaluate the antimicrobial properties and dental pulp stem cells (DPSCs) cytotoxicity of synthesized carboxymethyl cellulose-silver nanoparticles impregnated on titanium plates.Material and methods: The antibacterial effect of silver nanoparticles in a carboxymethyl cellulose matrix impregnated on titanium plates (Ti-AgNPs) in three concentrations: 16%, 50% and 100% was determined by adding these to bacterial cultures of Streptococcus mutans and Porphyromonas gingivalis . The Ti-AgNPs cytotoxicity on DPSCs was determined using a fluorimetric cytotoxicity assay with 0.12% chlorhexidine as a positive control.Results: Silver nanoparticles in all concentrations were antimicrobial, with concentrations of 50% and 100% being more cytotoxic with 4% cell viability. Silver nanoparticles 16% had a cell viability of 95%, being less cytotoxic than 0.12% chlorhexidine.Conclusions: Silver nanoparticles are a promising structure because of their antimicrobial properties. These have high cell viability at a concentration of 16%, and are less toxic than chlorhexidine.