Diagnostic performance of CD66c in lung adenocarcinoma-associated malignant pleural effusion: comparison with CEA, CA 19-9, and CYFRA 21-1. Issue 2 (February 2015)

• Record Type: Journal Article
• Authors: Son, Seung-Myoung; Han, Hye-Suk; An, Jin Young; Choe, Kang Hyeon; Lee, Ki Man; Lee, Ki Hyeong; Kim, So-Seul; Lee, Yong-Moon; Lee, Ho-chang; Song, Hyung Geun; Lee, Ok-Jun
• Is Part Of: Pathology. Volume 47:Issue 2(2015:Feb.)
• Publication Date: 2015-02
• Subjects: CA 19 -- CD66c -- CEA -- CEACAM6 -- CYFRA 21 -- lung adenocarcinoma -- pleural effusion; Pathology -- Periodicals; 616.0705
• DOI: 10.1097/PAT.0000000000000215
• Languages: English
• ISSNs: 0031-3025

Abstract

Abstract : Summary: Various tumour markers have been evaluated in malignant pleural effusions, but not CD66c. This study evaluated the diagnostic ability of CD66c in lung adenocarcinoma-associated malignant pleural effusions (LA-MPEs) and compared it with other known tumour markers. Forty-seven cases of LA-MPE and 52 cases of benign pleural effusions were collected. The levels of CD66c, CEA, CA 19-9, and CYFRA 21-1 were measured by enzyme immunoassay. The expression of CD66c, CEA, and CA 19-9 in cell blocks was measured by immunocytochemistry. CEA had the best diagnostic values, with a sensitivity of 87.2% and specificity of 92.3%. Both CD66c and CA 19-9 showed the highest specificity of 98.1%, with sensitivities of 63.8% and 55.3%, respectively. CYFRA 21-1 had a sensitivity of 83.0% and specificity of 76.9%. CEA combined with CA 19-9 reached a sensitivity of 91.5% and a specificity of 98.1%. The sensitivities of immunocytochemical staining for CD66c, CEA, and CA 19-9 were 72.5%, 75%, and 40%, respectively. CD66c showed a diagnostic performance comparable to CYFRA 21-1 and CA 19-9 by enzyme immunoassay. Immunocytochemical study showed that CD66c and CEA were more sensitive than CA19-9. Both studies support CD66c as a potential tumour marker to differentiate LA-MPE from benign effusions. Abstract : Supplemental Digital Content is available in the text