New insights into cell non-autonomous mechanisms of the C. elegans hypoxic response. Issue 2 (2nd April 2016)

• Record Type: Journal Article
• Authors: Leiser, Scott F.; Rossner, Ryan; Kaeberlein, Matt
• Is Part Of: Worm. Volume 5:Issue 2(2016)
• Publication Date: 2016-04-02
• Subjects: aging -- flavin-containing monooxygenase -- hypoxic signaling -- longevity -- serotonin; Caenorhabditis elegans -- Periodicals; 592.57
• DOI: 10.1080/21624054.2016.1176823
• Languages: English
• ISSNs: 2162-4046

Abstract

ABSTRACT: The hypoxic response is a well-studied and highly conserved biological response to low oxygen availability. First described more than 20 y ago, the traditional model for this response is that declining oxygen levels lead to stabilization of hypoxia-inducible transcription factors (HIFs), which then bind to hypoxia responsive elements (HREs) in target genes to mediate the transcriptional changes collectively known as the hypoxic response. 1, 2 Recent work in C. elegans has forced a re-evaluation of this model by indicating that the worm HIF (HIF-1) can mediate effects in a cell non-autonomous fashion and, in at least one case, increase expression of an intestinal hypoxic response target gene in cells lacking HIF-1.