Evaluating potential T-cell epitope peptides for detecting HIV-specific T cell responses in a highly diverse HIV-1 epidemic from Cameroon. (13th March 2015)

• Record Type: Journal Article
• Authors: Tongo, Marcel; Riou, Catherine; Crunchant, Eléonore; Müller, Tracey L.; Strickland, Natalie; Mpoudi-Ngole, Eitel; Burgers, Wendy A.
• Is Part Of: AIDS. Volume 29:Number 5(2015)
• Publication Date: 2015-03-13
• Subjects: AIDS (Disease) -- Periodicals; Acquired Immunodeficiency Syndrome; AIDS (Disease); Periodicals; Periodicals; 616.9792005
• DOI: 10.1097/QAD.0000000000000581
• Languages: English
• ISSNs: 0269-9370

Abstract

Abstract : HIV genetic diversity is a major obstacle for vaccine development. To define whether potential T-cell epitope (PTE) peptide usage improves the detection of T cell responses in a highly diverse HIV-1 epidemic, we compared the magnitude, breadth and depth of group M PTE peptide responses to consensus M peptides in Gag and Nef proteins. Gag PTE responses were detected at a higher magnitude, more Nef PTE responses were detected at a cohort (but not individual) level and depth was detected in both Gag and Nef responses.