Electronic control of DNA-based nanoswitches and nanodevices. Issue 1 (20th November 2015)

• Record Type: Journal Article
• Authors: Ranallo, Simona; Amodio, Alessia; Idili, Andrea; Porchetta, Alessandro; Ricci, Francesco
• Is Part Of: Chemical science. Volume 7:Issue 1(2016:Jan.)
• Page Start: 66
• Page End: 71
• Publication Date: 2015-11-20
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5sc03694a
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : Here we demonstrate that we can rationally and finely control the functionality of different DNA-based nanodevices and nanoswitches using electronic inputs. Abstract : Here we demonstrate that we can rationally and finely control the functionality of different DNA-based nanodevices and nanoswitches using electronic inputs. To demonstrate the versatility of our approach we have used here three different model DNA-based nanoswitches triggered by heavy metals and specific DNA sequences and a copper-responsive DNAzyme. To achieve electronic-induced control of these DNA-based nanodevices we have applied different voltage potentials at the surface of an electrode chip. The applied potential promotes an electron-transfer reaction that releases from the electrode surface a molecular input that ultimately triggers the DNA-based nanodevice. The use of electronic inputs as a way to finely activate DNA-based nanodevices appears particularly promising to expand the available toolbox in the field of DNA nanotechnology and to achieve a better hierarchical control of these platforms.