18fF-FDG PET/CT for Detection of Leukemic Transformation in Myelofibrosis. (June 2015)

• Record Type: Journal Article
• Authors: Derlin, Thorsten; Clauditz, Till Sebastian; Kröger, Nicolaus
• Is Part Of: Clinical nuclear medicine. Volume 40:Number 6(2015)
• Publication Date: 2015-06
• Subjects: myelofibrosis -- leukemia -- Richter syndrome -- leukemic transformation -- extramedullary -- PET/CT; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000000728
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: Myelofibrosis is a rare clonal hematopoietic stem cell disorder characterized by chronic myeloproliferation, atypical megakaryocytic hyperplasia, and potential leukemic transformation. We report a case of leukemic transformation detected by 18 F-FDG PET/CT. A 56-year-old woman with myelofibrosis and newly diagnosed space-occupying lesion of the chest wall underwent whole-body PET/CT for further evaluation. 18 F-FDG PET demonstrated marked tracer uptake within that lesion. Histopathological evaluation revealed myeloid sarcoma evidencing leukemic transformation. 18 F-FDG PET/CT is a valuable tool-enabling sensitive detection of leukemic transformation in myelofibrosis, particularly in case of extramedullary organ involvement.