Complete Response of Adult-Onset CNS Langerhans Cell Histiocytosis Documented on 18F-FDG PET/CT. (December 2015)

• Record Type: Journal Article
• Authors: Kruljac, Ivan; Balenović, Antonija; Gaćina, Petar; Imashuku, Shinsaku; Vrkljan, Milan
• Is Part Of: Clinical nuclear medicine. Volume 40:Number 12(2015)
• Publication Date: 2015-12
• Subjects: 18F-FDG PET/CT -- Langerhans cell histiocytosis -- chemotherapy -- vinblastine -- remission -- response; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000000994
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: We report a case of a 49-year-old woman with biopsy-proven multisystemic Langerhans cell histiocytosis (LCH) with hypothalamic involvement documented on 18 F-FDG PET/CT. Chemotherapy with a combination of vinblastine, prednisolone, methotrexate, and 6-mercaptopurine was carried out. Two months later, a 90% reduction of the hypothalamic tumor mass was noted on magnetic resonance imaging, but with no signs of pathological 18 F-FDG accumulation. The patient died 4 months later, and we found no signs of LCH on autopsy. Our case highlights the need for further studies regarding the role of 18 F-FDG PET/CT in the assessment of treatment response in patients with LCH.