Aniridic Glaucoma: Long-term Visual Outcomes and Phenotypic Associations. Issue 7 (September 2015)

• Record Type: Journal Article
• Authors: Jain, Amit; Gupta, Shikha; James, Mathew K.; Dutta, Paromita; Gupta, Viney
• Is Part Of: Journal of glaucoma. Volume 24:Issue 7(2015:Sep.)
• Publication Date: 2015-09
• Subjects: aniridia -- glaucoma -- visual outcome -- glaucoma surgery; Glaucoma -- Periodicals; 617.741005
• DOI: 10.1097/IJG.0000000000000019
• Languages: English
• ISSNs: 1057-0829

Abstract

Abstract : Purpose: The aim of this study was to evaluate long-term visual outcomes in patients with aniridic glaucoma. Design: Retrospective noncomparative observational case series. Materials and Methods: A review of medical records of 128 eyes of 64 consecutive patients with aniridic glaucoma, diagnosed after the age of 5 years was analyzed. The parameters studied included age at presentation, family history, baseline intraocular pressure (IOP), type and the number of surgical interventions, and associated comorbidities. Primary Outcome Measure: Best corrected visual acuity (BCVA) in the better eye. Results: Mean age at presentation was 15.86±10.11 years (range, 5 to 47 y). The average follow-up was 7.69±4.98 years (range, 1 to 17 y). At the final follow up only 18 patients had BCVA better than 6\60 and only 5 patients had BCVA of >6/18. Seventeen of the 64 (26.5%) patients developed phthisis in 1 eye. The final visual outcomes were not associated with age at presentation ( P =0.64) or sex ( P =0.76); however, those with a higher baseline IOP ( P =0.017), those with familial aniridia ( P =0.037), and those who underwent more number of surgical interventions had poorer visual outcomes ( P =0.004). Kaplan-Meier analysis demonstrated the probability of bilateral blindness to be 69.8% and 97.6% at 5 and 10 years, respectively. Conclusions: Long-term visual outcomes after therapy among aniridic glaucoma patients remain poor. Higher baseline IOP, the presence of familial aniridia, and a history of greater number of surgical interventions are associated with poorer long-term visual outcomes.