Conjunctival Melanoma With Morphologic Diversity and Orbital Invasion. (May 2016)

• Record Type: Journal Article
• Authors: Zoroquiain, Pablo; Nayman, Taylor; Fernandes, Bruno; Burnier, Miguel N.
• Is Part Of: American journal of dermatopathology. Volume 38:Number 5(2016)
• Publication Date: 2016-05
• Subjects: conjunctival melanoma -- morphologic diversity -- orbital invasion -- dysplastic nevi -- whole-slide image; Skin -- Diseases -- Periodicals; Histology, Pathological -- Periodicals; 616.50705
• DOI: 10.1097/DAD.0000000000000482
• Languages: English
• ISSNs: 0193-1091

Abstract

Abstract : Abstract: A 68-year-old male with a previous history of 3 dysplastic skin nevi was referred to ophthalmology for a 1-year history of a progressive growth of a firm nodule in the lower left eyelid. Examination revealed a firm nodule in the inferior anterior orbit and mild conjunctival pigmentation on the left inferior fornix. A conjunctival incisional biopsy was taken, showing a melanoma. Because of the infiltration by the mass of the orbit on magnetic resonance imaging, an exenteration was performed. Histopathological analysis showed a unique conjunctival melanoma showing morphological diversity; specifically, a pattern characteristic of conjunctival melanoma, and the concurrent presence of staghorn patterns, signet-ring cells, and rosettoid patterns. Seven years of follow-up shows that the patient is alive with no further metastasis or recurrence. This report represents the first documented case of multiple morphologic patterns within a conjunctival melanoma.