Peptides: Rational Design of Membrane‐Pore‐Forming Peptides (Small 40/2017). Issue 40 (20th October 2017)

• Record Type: Journal Article
• Authors: Pillong, Max; Hiss, Jan A.; Schneider, Petra; Lin, Yen‐Chu; Posselt, Gernot; Pfeiffer, Bernhard; Blatter, Markus; Müller, Alex T.; Bachler, Simon; Neuhaus, Claudia S.; Dittrich, Petra S.; Altmann, Karl‐Heinz; Wessler, Silja; Schneider, Gisbert
• Is Part Of: Small. Volume 13:Issue 40(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-10-20
• Subjects: antimicrobial peptide -- bioinformatics -- chemical biology -- drug discovery -- peptide design; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201770213
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : In article number1701316, by Gisbert Schneider and co‐workers, a novel peptide descriptor enables the rational design of peptides based on their topological hydrophobic distribution. Applying this descriptor, a computational method generates an innovative peptide inspired by a natural template. This peptide is then trialed and optimized for its ability to disrupt bacterial cells by forming ordered, pore‐like structures in membranes in an entropy‐driven mechanism.