Multi-site cyclization via initial C–H activation using a rhodium(iii) catalyst: rapid assembly of frameworks containing indoles and indolines. Issue 14 (12th January 2015)

• Record Type: Journal Article
• Authors: Huang, Ji-Rong; Qin, Liu; Zhu, Yu-Qin; Song, Qiang; Dong, Lin
• Is Part Of: Chemical communications. Volume 51:Issue 14(2015)
• Page Start: 2844
• Page End: 2847
• Publication Date: 2015-01-12
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c4cc07125e
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Tandem multi-site cyclization triggered by Rh(iii )-catalyzed C–H activation has been achieved for highly efficient synthesis of spirocycle indolin-3-one (C2-cyclization), benzo[ a ]carbazole (C3-cyclization) and an unusual indoxyl core (N1-cyclization). Abstract : Tandem multi-site cyclization triggered by Rh(iii )-catalyzed C–H activation has been achieved for highly efficient synthesis of spirocycle indolin-3-one (C2-cyclization), benzo[ a ]carbazole (C3-cyclization) and an unusual indoxyl core (N1-cyclization). In particular, the synthesis of pseudo-indoxyl is typically completed within 10 min, and the reaction tolerates air, water and a range of solvents.