A soft–hard template approach towards hollow mesoporous silica nanoparticles with rough surfaces for controlled drug delivery and protein adsorption. Issue 31 (16th July 2015)

• Record Type: Journal Article
• Authors: Zhang, Haijiao; Xu, Huijuan; Wu, Minghong; Zhong, Yufang; Wang, Donghai; Jiao, Zheng
• Is Part Of: Journal of materials chemistry. Volume 3:Issue 31(2015)
• Page Start: 6480
• Page End: 6489
• Publication Date: 2015-07-16
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c5tb00634a
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Novel hollow mesoporous silica nanoparticles (HMSNs) with rough surfaces have been successfully prepared using a facile soft–hard template route. Abstract : In this work, a novel type of hollow mesoporous silica nanoparticle (HMSN) with a rough surface has been successfully prepared via a facile soft–hard template route by using a carbon nanosphere as a hard template and cetyltrimethylammonium bromide (CTAB) as a soft template, respectively. This method involves the preparation of a carbon nanosphere, sequential coating of double SiO2 layers, and the removal of the inner carbon core and CTAB to produce HMSNs. The obtained HMSNs possess spherical morphology, a mesoporous shell, and crumpled surfaces. The controlled experiments prove that the addition of 3-ammonia propyl triethoxy silane (APTES) is very crucial for the formation of desired HMSNs. The cell tests indicate that HMSNs show a good biocompatibility. As a result, the potential applications of HMSNs are further explored for drug delivery and protein adsorption, using doxorubicin hydrochloride (DOX) and Cytochrome c (Cyt c ) as the model drug and protein, respectively. The HMSNs exhibit high drug loading and protein adsorption capacity, as well as the controlled pH-responsive release behavior for DOX. Therefore, the HMSNs prepared are ideal candidates for various applications such as nanoreactors, drug delivery and protein adsorption.