Disulfide-gated mesoporous silica nanoparticles designed for two-photon-triggered drug release and imaging. Issue 31 (13th July 2015)

• Record Type: Journal Article
• Authors: Croissant, Jonas G.; Qi, Christian; Mongin, Olivier; Hugues, Vincent; Blanchard-Desce, Mireille; Raehm, Laurence; Cattoën, Xavier; Wong Chi Man, Michel; Maynadier, Marie; Gary-Bobo, Magali; Garcia, Marcel; Zink, Jeffrey I.; Durand, Jean-Olivier
• Is Part Of: Journal of materials chemistry. Volume 3:Issue 31(2015)
• Page Start: 6456
• Page End: 6461
• Publication Date: 2015-07-13
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c5tb00797f
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : We report two-photon cancer cell killing through mesoporous silica nanogates. Abstract : We report a two-photon-actuated cancer cell killing system that kills the cancer cells via drug delivery through multifunctional mesoporous silica nanogates. Two-photon-sensitive mesoporous organosilica (M2PS) nanocarriers were synthesized via the co-condensation of a silica precursor and a two-photon electron donor. The nanogates were constructed using a fast one-pot process at room temperature on the drug-loaded M2PS nanoparticles (NPs) with the bis(3-triethoxysilylpropyl)disulfide precursor. One and two-photon-actuated cargo releases from the M2PS nanogates were successfully monitored in aqueous solutions. Furthermore, the cellular uptake in MCF-7 cells was demonstrated via two-photon fluorescence imaging of the NPs, which were then applied successfully for drug delivery in cells.