Host–guest chemistry that directly targets lysine methylation: synthetic host molecules as alternatives to bio-reagents. Issue 66 (4th July 2016)

• Record Type: Journal Article
• Authors: Hof, Fraser
• Is Part Of: Chemical communications. Volume 52:Issue 66(2016)
• Page Start: 10093
• Page End: 10108
• Publication Date: 2016-07-04
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc04771h
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Post-translational methylation regulates the function of hundreds of proteins in profound ways, and is the target of many efforts to use host–guest chemistry to solve biochemical and biological problems. Abstract : Post-translational methylation is a chemically simple modification, but regulates the function of hundreds of proteins in profound ways. This Feature Article will report on the basic aspects of protein methylation, and will offer a personal perspective on our recent efforts at making supramolecular hosts that can bind and discriminate among post-translationally methylated partners. The article highlights several general lessons drawn from these efforts and related work by other groups. It also describes some ways in which supramolecular approaches are inherently well suited to provide tools that drive new research in the life sciences.