Vasodilators in Septic Shock Resuscitation: A Clinical Perspective. Issue 3 (March 2017)

• Record Type: Journal Article
• Authors: Corrêa, Thiago Domingos; Filho, Roberto Rabello; Assunção, Murillo Santucci Cesar; Silva, Eliézer; Lima, Alexandre
• Is Part Of: Shock. Volume 47:Issue 3(2017)
• Publication Date: 2017-03
• Subjects: Microcirculation -- multiple organ failure -- nitric oxide -- nitroglycerin -- resuscitation -- sepsis -- septic shock -- vasodilator agents; Shock -- Periodicals; Shock -- Periodicals; Choc (Pathologie) -- Périodiques; Shock; Periodicals; 616.0475
• DOI: 10.1097/SHK.0000000000000777
• Languages: English
• ISSNs: 1073-2322

Abstract

Abstract : ABSTRACT: Microcirculatory abnormalities have been shown to be frequent in patients with septic shock despite "normalization" of systemic hemodynamics. Several studies have explored the impact of vasodilator therapy (prostacyclin, inhaled nitric oxide, topic acetylcholine, and nitroglycerin) on microcirculation and tissue perfusion, with contradictory findings. In this narrative review, we briefly present the pathophysiological aspects of microcirculatory dysfunction, and depict the evidence supporting the use of vasodilators and other therapeutic interventions (fluid administration, blood transfusion, vasopressors, and dobutamine) aiming to improve the microcirculatory flow in septic shock patients.