Pediatric Brain Tumors: Current Knowledge and Therapeutic Opportunities. Issue 4 (May 2016)

• Record Type: Journal Article
• Authors: Glod, John; Rahme, Gilbert J.; Kaur, Harpreet; H. Raabe, Eric; Hwang, Eugene I.; Israel, Mark A.
• Is Part Of: Journal of pediatric hematology/oncology. Volume 38:Issue 4(2016)
• Publication Date: 2016-05
• Subjects: pediatric glioma -- medulloblastoma -- diffuse intrinsic pontine glioma -- ependymoma -- SEGA; Pediatric hematology -- Periodicals; Tumors in children -- Periodicals; 618.9215
• DOI: 10.1097/MPH.0000000000000551
• Languages: English
• ISSNs: 1077-4114

Abstract

Abstract : Great progress has been made in many areas of pediatric oncology. However, tumors of the central nervous system (CNS) remain a significant challenge. A recent explosion of data has led to an opportunity to understand better the molecular basis of these diseases and is already providing a foundation for the pursuit of rationally chosen therapeutics targeting relevant molecular pathways. The molecular biology of pediatric brain tumors is shifting from a singular focus on basic scientific discovery to a platform upon which insights are being translated into therapies.