DNA hydrogel delivery vehicle for light-triggered and synergistic cancer therapy. Issue 21 (11th May 2015)

• Record Type: Journal Article
• Authors: Song, Jaejung; Im, Kyuhyun; Hwang, Sekyu; Hur, Jaehyun; Nam, Jutaek; Ahn, G-One; Hwang, Sungwoo; Kim, Sungjee; Park, Nokyoung
• Is Part Of: Nanoscale. Volume 7:Issue 21(2015)
• Page Start: 9433
• Page End: 9437
• Publication Date: 2015-05-11
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c5nr00858a
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : A drug delivery vehicle has been prepared by combining gold nanorods and a DNA intercalated drug in a DNA hydrogel, resulting in thermo-chemo combination therapy with photothermal-triggered DNA melting and release of doxorubicin. Abstract : A DNA hydrogel is reported as a delivery vehicle for gold nanorods and doxorubicin. The two photothermal and chemo cancer agents were co-loaded using electrostatic and DNA binding interactions, respectively. Light-triggered and highly synergistic combination cancer therapy was demonstrated in cellular and animal models.