PET-CT for Evaluation of Spleen and Liver 18F-FDG Diffuse Uptake Without Lymph Node Enlargement in Lymphoma. Issue 20 (May 2016)

• Record Type: Journal Article
• Authors: Rao, Liangjun; Wang, Xiaoyan; Zong, Zhen; Chen, Zhifeng; Shi, Xinchong; Yi, Chang; Zhang, Xiangsong; Yang, Zhiyun
• Editors: Masoomi., Michael
• Is Part Of: Medicine. Volume 95:Issue 20(2016)
• Page Start: e3750
• Publication Date: 2016-05
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000003750
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Abstract: The aim of the study was to compare differences between lymphoma and inflammation as indicated by high diffuse uptake of 18 F-fluorodeoxyglucose ( 18 F-FDG) in the spleen, liver, and bone marrow without increased 18 F-FDG uptake in the lymph nodes and without enlarged peripheral lymph nodes. Eighteen lymphoma patients and 14 inflammation patients were examined with 18 F-FDG positron emission tomography–computer tomography (PET-CT). All patients displayed high diffuse uptake of 18 F-FDG in the spleen, liver, and bone marrow without increased 18 F-FDG uptake in the lymph nodes and without enlarged peripheral lymph nodes. Our analyses compared the maximum standardized uptake values (SUVmax) of 18 F-FDG uptake ratios between the spleen/liver, the spleen/bone marrow, and the liver/bone marrow and further compared spleen sizes between lymphoma and inflammation patients. Using Student t test, no significant differences were found in the SUVmax ratios of spleen/liver and liver/bone marrow between the lymphoma and inflammation patients ( t = 0.853, P = 0.401 > 0.05; t = 1.622, P = 0.115 > 0.05). However, the SUVmax ratio of the spleen/bone marrow of the lymphoma patients was significantly different from that of the inflammation patients ( t = 2.426, P = 0.021 < 0.05). The spleen size between the lymphoma and inflammation patients was also significantly different ( t = 2.911, P = 0.007 < 0.05). As indicated by 18 F-FDG PET-CT, our study demonstrated that lymphoma and inflammation patients displayed a few differences despite both having high diffuse uptake of 18 F-FDG in the spleen, liver, and bone marrow without enlarged peripheral lymph nodes and without increased 18 F-FDG uptake in lymph nodes.