Association of Systemic Inflammatory Response Syndrome with Clinical Outcomes of Pediatric Patients with Pneumonia. Issue 11 (November 2015)

• Record Type: Journal Article
• Authors: Frazier, Steven Barron; Sepanski, Robert; Mangum, Christopher; Bovat, Christine; Zaritsky, Arno; Godambe, Sandip
• Is Part Of: Southern medical journal. Volume 108:Issue 11(2015)
• Publication Date: 2015-11
• Subjects: community acquired pneumonia -- emergency department -- pediatric pneumonia severity -- screening tool -- systemic inflammatory response syndrome; Medicine -- Periodicals; 610.5
• DOI: 10.14423/SMJ.0000000000000362
• Languages: English
• ISSNs: 0038-4348

Abstract

Abstract : Objectives: Systemic inflammatory response syndrome (SIRS) may complicate pneumonia. When present, it suggests that the patient's pneumonia is more severe. As such, recognition of SIRS among patients with pneumonia may be helpful in identifying those requiring more careful evaluation. Our objective was to examine the relation between the presence of SIRS and adverse clinical outcomes among children with pneumonia seen in the emergency department (ED). Methods: A retrospective chart review was performed on children diagnosed as having community-acquired pneumonia who presented to a children's hospital ED during a 3-month period. SIRS was determined by using a modification of the International Consensus Conference on Pediatric Sepsis criteria. Specifically, the SIRS criteria require an abnormal temperature–corrected heart rate or respiratory rate and either an abnormal temperature or white blood cell count. The threshold for abnormal vital signs and white blood cell counts used to determine SIRS was adjusted based on the patient's age. Morbidity endpoints included progression to inpatient or observation status or subsequent return to the ED for pneumonia, need for video-assisted thoracoscopic surgery, and total hospital length of stay as measured from ED triage assessment to final discharge from the hospital (ED, observation, or inpatient), and the need for mechanical ventilation. Results: A total of 276 children were included in the analysis. Pneumonia patients with SIRS (n = 38) had a greater rate of hospital admission or ED return compared with SIRS-negative patients (n = 238; 79% vs 34.5%, respectively; P < 0.0001). Children with SIRS-positive pneumonia were at greater risk of requiring video-assisted thoracoscopic surgery (18.4% vs 0.8%; P < 0.0001). In addition, pneumonia patients with SIRS had a significantly longer median length of stay compared with pneumonia patients without SIRS (2.7 vs 0.19 days, P < 0.0001) and also had a significantly higher risk of mechanical ventilation (10.5% vs 0.8%). Conclusions: SIRS in children with community-acquired pneumonia is associated with a significantly higher likelihood of experiencing a more adverse outcome. Based on these observations, a sepsis screening tool in the ED that identifies SIRS in children with pneumonia has the potential to identify those children needing more intense monitoring and treatment. Abstract : Community-acquired pneumonia remains one of the deadliest diseases to treat and when severe, can progress to sepsis. The ability to quickly interpret the severity of pneumonia in a critical care setting has improved within the adult population with the creation of screening tools; however, screening tools have not been created to assist in the care of children. This article shows the successful use of the systemic inflammatory response syndrome criteria to stratify severity of disease and helps predict the outcomes of children with community-acquired pneumonia.