The Role of Inhibition in Epileptic Networks. Issue 3 (June 2015)

• Record Type: Journal Article
• Authors: Trevelyan, Andrew J.; Muldoon, Sarah F.; Merricks, Edward M.; Racca, Claudia; Staley, Kevin J.
• Is Part Of: Journal of clinical neurophysiology. Volume 32:Issue 3(2015)
• Publication Date: 2015-06
• Subjects: epilepsy -- seizure -- GABA -- interneuron -- chloride; Electroencephalography -- Periodicals; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electroencephalography; Periodicals; 612.805
• DOI: 10.1097/WNP.0000000000000160
• Languages: English
• ISSNs: 0736-0258

Abstract

Abstract : Summary: Inhibition plays many roles in cortical circuits, including coordination of network activity in different brain rhythms and neuronal clusters, gating of activity, gain control, and dictating the manner in which activity flows through the network. This latter is particularly relevant to epileptic states, when extreme hypersynchronous discharges can spread across cortical territories. We review these different physiological and pathological roles and discuss how inhibition can be compromised and why this predisposes the network to seizures.